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Adams, Erin J.
One or more keywords matched the following properties of Adams, Erin J.
PropertyValue
keywords MHC (nonclassical and MHC-like)
overview Our laboratory is interested in the molecular signals that are used by the immune system to distinguish healthy from unhealthy tissue. Many of our projects focus on “unconventional” T cell recognition, involving ?d T cells, Natural Killer T cells and Muscosal-Associated Invariant T (MAIT) cells and antigen presentation by nonclassical or MHC-like proteins. Our strengths are in biochemistry, structural biology, protein engineering and cellular assays that will reveal the fundamental principles behind how effector cells of the immune system regulate human disease. We have a high level of expertise in studying molecular recognition of T cells, particularly unconventional T cells outside the canonical CD4+/CD8+ lineage and structure function of antigen-presenting molecules.
One or more keywords matched the following items that are connected to Adams, Erin J.
Item TypeName
Concept Genes, MHC Class I
Academic Article ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion.
Academic Article The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR.
Academic Article A novel, nonclassical MHC class I molecule specific to the common chimpanzee.
Academic Article NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C.
Academic Article Genomic analysis of common chimpanzee major histocompatibility complex class I genes.
Academic Article Analysis of a successful immune response against hepatitis C virus.
Academic Article A major histocompatibility complex class I allele shared by two species of chimpanzee.
Academic Article Species-specific evolution of MHC class I genes in the higher primates.
Academic Article Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Academic Article Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes).
Academic Article An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells.
Academic Article Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus.
Academic Article Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes.
Academic Article Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.
Academic Article The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.
Academic Article Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells.
Academic Article High diversity of MIC genes in non-human primates.
Academic Article Coevolution of T-cell receptors with MHC and non-MHC ligands.
Academic Article The presence of HLA-A*2403 and HLA-B*1512 on the same haplotype in a Thai family.
Academic Article Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
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